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Valacyclovir: A Substrate for the Intestinal and Renal Peptide Transporters PEPT1 and PEPT2

โœ Scribed by Malliga E. Ganapathy; Wei Huang; Hong Wang; Vadivel Ganapathy; Frederick H. Leibach


Book ID
115582082
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
124 KB
Volume
246
Category
Article
ISSN
0006-291X

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In clinical trials, valganciclovir, the valyl ester of ganciclovir, has been shown to enhance the bioavailability of ganciclovir when taken orally by patients with cytomegalovirus infection. We investigated the role of the intestinal peptide transporter PEPT1 in this process by comparing the interac