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Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2

✍ Scribed by Tomohiro Terada; Kyoko Sawada; Megumi Irie; Hideyuki Saito; Yukiya Hashimoto; Ken-ichi Inui


Book ID
106110951
Publisher
Springer
Year
2000
Tongue
English
Weight
126 KB
Volume
440
Category
Article
ISSN
0031-6768

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Peptide transporter 1 is responsible for
✍ Katherine Ma; Yongjun Hu; David E. Smith πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 304 KB

The purpose of this study was to determine the relative importance of peptide transporter 1 (PEPT1) in the uptake of peptides/mimetics from mouse small intestine, using glycylsarcosine (GlySar). After isolating jejunal tissue from wild-type and Pept1 null mice, 2 cm intestinal segments were everted