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Identification of a Potential Substrate Binding Domain in the Mammalian Peptide Transporters PEPT1 and PEPT2 Using PEPT1-PEPT2 and PEPT2-PEPT1 Chimeras

✍ Scribed by You-Jun Fei; Jin-Cai Liu; Takuya Fujita; Rong Liang; Vadivel Ganapathy; Frederick H. Leibach

Book ID
115582028
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
191 KB
Volume
246
Category
Article
ISSN
0006-291X

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Transport of valganciclovir, a ganciclov
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In clinical trials, valganciclovir, the valyl ester of ganciclovir, has been shown to enhance the bioavailability of ganciclovir when taken orally by patients with cytomegalovirus infection. We investigated the role of the intestinal peptide transporter PEPT1 in this process by comparing the interac