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Utilization of thiazolylacetonitriles in the synthesis of thiophene, thiazole, pyrazolo[1,5-a]pyrimidine and pyrazolo [5,1-c]triazine derivatives

✍ Scribed by Abdou O. Abdelhamid; Hussein F. Zohdi; Gaber S. Mohamed

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 291 KB
Volume: 10
Category: Article
ISSN: 1042-7163
DOI: 10.1002/(sici)1098-1071(1999)10:6<508::aid-hc12>3.0.co;2-w

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✦ Synopsis

Thiazolylcyanothioacetanilides react with ␣-haloketones and haloesters to give the corresponding thiophene or thiazole derivatives according to the reaction conditions. Pyrazolo [1,5-a]pyrimidines and pyrazolo [5,1-c]triazines were synthesized by reaction of 3-amino-4-(4Ј-arylthiazol-2Ј-yl)-5-phenylaminopyrazole with different reagents. Structures of the new compounds were confirmed by elemental analyses, spectral data, and alternative methods of synthesis whenever possible.

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