Activated Nitriles in Heterocyclic Chemistry. A Novel Synthesis of Pyridones, Pyrazolo[1,5-a]pyrimidines and Pyrazolo[1,5-b]oxazines
โ Scribed by Mohamed A. E. Khalifa; Gamal H. Tammam; Hadeer M. Bakeer
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 203 KB
- Volume
- 317
- Category
- Article
- ISSN
- 0365-6233
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๐ SIMILAR VOLUMES
Thiazolylcyanothioacetanilides react with โฃ-haloketones and haloesters to give the corresponding thiophene or thiazole derivatives according to the reaction conditions. Pyrazolo [1,5-a]pyrimidines and pyrazolo [5,1-c]triazines were synthesized by reaction of 3-amino-4-(4ะ-arylthiazol-2ะ-yl)-5-phenyl
## 2-Acetylbenzothiazole (1) reacts with dimethylformamide dimethylacetal (DMF-DMA) to afford the enaminone 2. Compound 2 reacts regioselectively with some nitrilimines 5a-d and nitrile oxides 6b-d to afford the novel pyrazole and isoxazole derivatives 11a-d and 12b-d, respectively, which react wi