Eingegangen am 16. Juli 1986 New 3-(pyridin-6-yl) pyraolo [ 1,5-u]pyrimidines were synthesized from (pyridin-6-y1)malonodinitrile 58, ethyl (pyridin-6-y1)cyanoacetate 5b and (pyridin-6-y1)benzoylacetonitrile 5c. Compounds 58-c were obtained from the 4,4,4-trichlorobut-2-enenitriles 2 and 1-pheny1et
Synthesis of Some New Pyrazolo[4,3-B]Pyridine, Pyridine, Pyrazolo[1,5-A]Pyrimidine and Thiazole Derivatives
โ Scribed by Fathy M. A. El-Taweel
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 414 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0037-9646
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m. p.=248-250GC (dec.; from methanol); [.ID= -129.' (DMSO, c = 1.00); 'H-NMR (D6-DMSO); t=4.13 and 4.18 (s, I-H+l'-H and s, 2 2-benzyl-H, or vice versa); MS: 520 (M+)]. The amino ketone ( 8 ) is probably first formed, being later aromatized by dimerization and air oxidation to yield ( 9 ) . The firs
Thiazolylcyanothioacetanilides react with โฃ-haloketones and haloesters to give the corresponding thiophene or thiazole derivatives according to the reaction conditions. Pyrazolo [1,5-a]pyrimidines and pyrazolo [5,1-c]triazines were synthesized by reaction of 3-amino-4-(4ะ-arylthiazol-2ะ-yl)-5-phenyl
The assignments of 'H and 13C NMR spectra of new 1 H-pyrazolo[3,4-b]pyridine derivatives based on I D and 2D NMR techniques, are reported.