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Synthesis of Pyrazolo[5,1–c][1,2,4]triazines, Isoxazolo[3,4-e]pyrazolo-[5,1–c][1,2,4]triazines and Aminopyridones

✍ Scribed by Kamal U. Sadek; Nadia S. Ibrahim; Mohamed H. Elnagdi

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
236 KB
Volume
321
Category
Article
ISSN
0365-6233

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The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.

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