Reactions with 4-(Cyanoacetyl)phenazone: Synthesis of Novel Thiazole, Hydrazinopyrazole and Pyrazolo[5.1-c][1.2.4]triazine Derivatives
β Scribed by Abdel Ghani A. Elagamey; Fathey A. El Taweel; Fathey A. Amer; Hanafy H. Zoorob
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 293 KB
- Volume
- 320
- Category
- Article
- ISSN
- 0365-6233
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π SIMILAR VOLUMES
The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.
Benzofuroylhydroxamoyl chloride (3) reacted with acrylonitrile, N-tolylmaleimide and active methylene compounds to afford the isoxazoline 4, the pyrrolidino13,4-d]isozazoline 5 and the isoxazole derivatives 6, 7, respectively. Nitrosoirnidazo[ 1,2-alpyridines 10 and the imidazo[ 1,2-alpyrimidine 12
6-Tri-tert-butyl-1,3,5-triphosphabenzene 4 reacts with to the 1,3,4,7-tetraphosphasemibullvalene derivative 10 as the only product. The single-crystal X-ray analysis of 10 phosphaalkynes PΟ΅CΟͺR [R = tBu (5a), tPen (5b)] at room temperature in a formal [4 + 2] cycloaddition to yield the exhibits a dip