Synthesis and In Vitro Antibacterial Evaluation of Novel Imidazo[2′, 1′:5, 1]-1, 2, 4-triazolo[4, 3-c]-quinazoline Derivatives of 5-Thioxo-1, 2, 4-triazole, 4-Oxothiazolidine, and their Open-chain Counterparts
✍ Scribed by Magda N. Nasr; Magdy M. Gineinah; Eman R. El-Bendary
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 96 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0365-6233
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📜 SIMILAR VOLUMES
Hydrazonoyl bromides 1a-c react with 5-amino-3phenyl-1H-pyrazole, 5-amino-1H-1,2,4-triazole, 2aminopyridine, 2-aminopyrimidine, and 2-aminobenzimidazole to afford the corresponding imidazo[1,2-b]pyrazoles 10, imidazo[1,2-b]-1,2,4-triazoles 11, imidazo[1,2-a]pyridines 16, imidazo[1,2-a]pyrimidines 17
## Abstract The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4__H__‐1, 2, 4‐triazoles (**4a—6f**) were synthesized and tested __in vitro__ for their antibacterial and antifungal activities
and 3-aminopyrazole and 3-amino-1,2,4-triazole provide convenient access to biologically relevant 3H-imidazo[1,2-b]pyrazoles and a 5H-imidazo[2,1-c][1,2,4]triazole.
With sodium borohydride in tetrahydrofuran/ethanol (5 : 1). the product ( I ) gives a 75 yield of a compound, m.p. 233 "C, that is identical with the recently prepared 2-(diphenylmethyl)imidaz0le[~1. When product ( I ) is boiled for 2 h in tetrahydrofuran/water (2: I ) it affords 2-(hydroxy-dipheny