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Synthesis and in vitro Antimicrobial Evaluation of 5-(1-Methyl-5-nitro-2-imidazolyl)-4H-1, 2, 4-triazoles

✍ Scribed by Abbas Shafiee; Abolfazl Sayadi; Marjan Hosseini Roozbahani; Alireza Foroumadi; Fatemeh Kamal

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 60 KB
Volume: 335
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200290004

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4__H__‐1, 2, 4‐triazoles (4a—6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5—1 μg/mL and moderate effects against Staphylococcus aureus.

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