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Synthesis of 2-methyl-4(5)-nitro[15N1(3)]imidazole from 2-methyl-4(5)-nitroimidazole

✍ Scribed by Jerzy Suwiński; Wojciech Szczepankiewicz

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
330 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

A simple four-stage conversion of 2-1nethyl-4(5>nitroimidazole to 2-methyl-4(5)-nitr0['~N""]imidazole is reported. The method consists in N-nitration of the initial compound to ?-methyl-1,4-dinitroimidazole, treating the latter with ["Nlglycine and N-dealkylation of the obtained (~-rnethyl-4-nitro[~'N']imidazol-l-yl)acetic acid through its bromination in the presence of phosphorus trichloride, followed by the hydrolysis of the non-isolated intermediate.

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