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Synthesis and In-Vitro Antibacterial Activity of 5-Substituted 1-Methyl-4-nitro-1H-imidazoles

✍ Scribed by Bahram Letafat; Saeed Emami; Alireza Aliabadi; Negar Mohammadhosseini; Mohammad Hassan Moshafi; Ali Asadipour; Abbas Shafiee; Alireza Foroumadi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
321 KB
Volume
341
Category
Article
ISSN
0365-6233

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## Abstract The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4__H__‐1, 2, 4‐triazoles (**4aβ€”6f**) were synthesized and tested __in vitro__ for their antibacterial and antifungal activities

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A simple four-stage conversion of 2-1nethyl-4(5>nitroimidazole to 2-methyl-4(5)-nitr0['~N""]imidazole is reported. The method consists in N-nitration of the initial compound to ?-methyl-1,4-dinitroimidazole, treating the latter with ["Nlglycine and N-dealkylation of the obtained (~-rnethyl-4-nitro[~