๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Use of 2-methylsulfonylethyl as a phosphorus protecting group in oligonucleotide synthesis via a phosphite triester approach

โœ Scribed by C. Claesen; G.I. Tesser; C.E. Dreef; J.E. Marugg; G.A. van der Marel; J.H. van Boom

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
204 KB
Volume
25
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

2-Methylsulfonylethoxy dichlorophosphine has been converted into the mono-N-morpholino derivative and applied for the preparation of 5'-D,N-protected d-nucleoside-3'-phosphoramidites. The latter intermediates could be used in the presence of 1-hydroxyben~otriazole for the formation of 3'-5'-phosphotriester linkages. The MSE protecting group can be removed selectively and fast under mild basic conditions.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of oligonucleotides via phosph
Synthesis of oligonucleotides via phosphoramidite approach utilizing 2-diphenylmethylsilylethyl (DPSE) as a phosphorus protecting group
โœ Vasulinga T. Ravikumar; Tadeusz K. Wyrzykiewicz; Douglas L. Cole ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 816 KB

Absbwct: 2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for internucleotidic bonds in the synthesis of oligodeoqribo nucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild /3$ragmentation conditions using aqueous ammonium hyd

4-Cyano-2-butenyl group: A new type of p
4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach
โœ Vasulinga T. Ravikumar; Zacharia S. Cheruvallath; Douglas L. Cole ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

4-Cyano-2-butenyl (CB) is a new type of protecting group for the intemucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a 8-elimination pathway using aqueous ammonium h