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Synthesis of oligonucleotides via phosphoramidite approach utilizing 2-diphenylmethylsilylethyl (DPSE) as a phosphorus protecting group

โœ Scribed by Vasulinga T. Ravikumar; Tadeusz K. Wyrzykiewicz; Douglas L. Cole

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
816 KB
Volume
50
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Absbwct: 2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for internucleotidic bonds in the synthesis of oligodeoqribo nucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild /3$ragmentation conditions using aqueous ammonium hydroxide.

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