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4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

โœ Scribed by Vasulinga T. Ravikumar; Zacharia S. Cheruvallath; Douglas L. Cole

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
258 KB
Volume
37
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

4-Cyano-2-butenyl (CB) is a new type of protecting group for the intemucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a 8-elimination pathway using aqueous ammonium hydroxide.

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