2-Methylsulfonylethoxy dichlorophosphine has been converted into the mono-N-morpholino derivative and applied for the preparation of 5'-D,N-protected d-nucleoside-3'-phosphoramidites. The latter intermediates could be used in the presence of 1-hydroxyben~otriazole for the formation of 3'-5'-phosphot
Use of 2-cyano-1,1-dimethylethyl as a protecting group in the synthesis of DNA VIA phosphite intermediates
โ Scribed by J. E. Marugg; C. E. Dreef; G. A. van der Marel; J. H. van Boom
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 172 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0165-0513
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๐ SIMILAR VOLUMES
4-Cyano-2-butenyl (CB) is a new type of protecting group for the intemucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a 8-elimination pathway using aqueous ammonium h
The hexafluoro-2-butyl (HFB) group is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxydbonuclootides by the phosphoramidite approach. This group can be removed rapidly under the same condition as the 2--eyanoethyl group. Furthermore, we have found that the phosphityla