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Use of the hexafluoro-2-butyl protecting group in the synthesis of DNA fragments via the phosphoramidite approach on solid supports

✍ Scribed by Sung-Gug Kim; Kouichi Eida; Hiroshi Takaku

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 210 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00269-y

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✦ Synopsis

The hexafluoro-2-butyl (HFB) group is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxydbonuclootides by the phosphoramidite approach. This group can be removed rapidly under the same condition as the 2--eyanoethyl group. Furthermore, we have found that the phosphitylating agent, hexafluoro-2-butyl-N.N-dialkylaminochlorophosphine, is easy to prepare in terms of its stability during purification by distillation, which does not require high vacuum.

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