𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Use of an allylic anchor group and of its palladium catalyzed hydrostannolytic cleavage in the solid phase synthesis of protected peptide fragments

✍ Scribed by F. Guibé; O. Dangles; G. Balavoine; A. Loffet

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
209 KB
Volume
30
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

protected The allylic handle -0-CH2-CH-CH-CH2-0-CH2-CO-has been used in the synthesis of peptide fro ments on aminomethyl polystyrene. The palladium-catalyzed hydrostannolytic cleavage il of t e peptide fragments from the resin occurs under very mild conditions.

📜 SIMILAR VOLUMES

Solid-phase synthesis of peptides using
Solid-phase synthesis of peptides using allylic anchoring groups 2. Palladium-catalysed cleavage of Fmoc-protected peptides
✍ Paul Lloyd-Williams; Ahmed Merzouk; François Guibé; Fernando Albericio; Ernest G 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 384 KB

High yklds for the cleavage reaction of Fmoc-protected peptide segments fmn an allylic handle may be obtained using tributyltin hydride in the jmsence of (ph3P)PdQ in a 1:l mixture of DMF/DCM. Altematively tbe cleavage reacdon may be carried out using NMA as nuclecpbile in a 2:2:1 mixture of DMSOfl'

Solid-phase synthesis of peptides using
Solid-phase synthesis of peptides using allylic anchoring groups. An investigation of their palladium-catalysed cleavage
✍ Paul Lloyd-Williams; Gemma Jou; Fernando Albericio; Ernest Giralt 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 363 KB

The use of two dlfferent allylx "handles" has been mvcstlgated m the s&d-phase synthesis of protected peptldes Very iilgh ylcld3 for the cleavage ofpeptldes from the resin, under mdd condmons which preserve sidecham protcctmg groups can be achieved by caqmg out the cleavage reactmn m 2 2 1 THF/DMSO/

ChemInform Abstract: Nα-Alloc Temporary
ChemInform Abstract: Nα-Alloc Temporary Protection in Solid-Phase Peptide Synthesis. The Use of Amine—Borane Complexes as Allyl Group Scavengers.
✍ Paloma Gomez-Martinez; Michele Dessolin; Francois Guibe; Fernando Albericio 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 39 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v