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Solid-phase synthesis of peptides using allylic anchoring groups. An investigation of their palladium-catalysed cleavage

✍ Scribed by Paul Lloyd-Williams; Gemma Jou; Fernando Albericio; Ernest Giralt

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 363 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79906-0

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✦ Synopsis

The use of two dlfferent allylx "handles" has been mvcstlgated m the s&d-phase synthesis of protected peptldes Very iilgh ylcld3 for the cleavage ofpeptldes from the resin, under mdd condmons which preserve sidecham protcctmg groups can be achieved by caqmg out the cleavage reactmn m 2 2 1 THF/DMSO/O 5 M HCI,

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