Use of 2-trimethylsilylethyl as a protecting group in phosphate monoester synthesis
โ Scribed by Akiyoshi Sawabe; Sandra A. Filla; Satoru Masamune
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 170 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The 1,1,1,3,3,3-Hexafluoro-2-propyl group can be used as a new class of phosphate protecting group for the protecting group of internucleotidic bonds in the oligonucleotide synthesis by the phosphotriester approach . This protecting group is removed easily by treatment with 0 .3 M N 1 ,N 1 ,N 3 ,N''
2-Methylsulfonylethoxy dichlorophosphine has been converted into the mono-N-morpholino derivative and applied for the preparation of 5'-D,N-protected d-nucleoside-3'-phosphoramidites. The latter intermediates could be used in the presence of 1-hydroxyben~otriazole for the formation of 3'-5'-phosphot