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2-(trimethylsilyl)ethyl as a phosphate protecting group in oligonucleotide synthesis

✍ Scribed by Takeshi Wada; Mitsuo Sekine


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
279 KB
Volume
35
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


A novel phosphate protection for oligonu
✍ Andrei P Guzaev; Muthiah Manoharan πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 104 KB

The utility of the 2-(arylcarbamoyloxy)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. Of the three protecting groups tested, the 2-[(1-naphthyl)carbamoyloxy]ethyl demonstrated high coupling yields, favorable deprotection kinetics and the h