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Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells

✍ Scribed by Kassi, E.; Sourlingas, T. G.; Spiliotaki, M.; Papoutsi, Z.; Pratsinis, H.; Aligiannis, N.; Moutsatsou, P.


Book ID
120925185
Publisher
Informa plc
Year
2009
Tongue
English
Weight
450 KB
Volume
27
Category
Article
ISSN
0735-7907

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A study of MCF-7 human breast cancer cells was undertaken to ascertain the degree of apoptosis induction by paclitaxel and if the induction of apoptosis could be enhanced by caffeine. Paclitaxel (0-20 ng/ml) caused concentration-dependent increases in morphologically identifiable apoptotic cells (up