𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Overexpression of basic fibroblast growth factor (FGF–2) downregulates Bcl–2 and promotes apoptosis in MCF–7 human breast cancer cells

✍ Scribed by Paul Maloof; Qin Wang; Huisheng Wang; Dana Stein; Thomas N. Denny; Joachim Yahalom; Eyal Fenig; Robert Wieder


Book ID
110233610
Publisher
Springer US
Year
1999
Tongue
English
Weight
250 KB
Volume
56
Category
Article
ISSN
0167-6806

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Overexpression of basic fibroblast growt
✍ Robert Wieder; Eyal Fenig; Huisheng Wang; Qin Wang; Shoshana Paglin; Thomas Menz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 606 KB

Basic fibroblast growth factor (bFGF, FGF-2) is progressively lost from mammary epithelial cells as they become malignant. To investigate the effects of restoring the expression of bFGF in breast cancer cells, we constructed MCF-7 cells that permanently overexpress 18-kD cytoplasm-localizing bFGF (M

Down-regulation of apoptosis-related bcl
✍ Besim Ogretmen; Ahmad R. Safa 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 797 KB

Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-