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Basic Fibroblast Growth Factor Downregulates Bcl-2 and Promotes Apoptosis in MCF-7 Human Breast Cancer Cells

✍ Scribed by Qin Wang; Paul Maloof; Huisheng Wang; Eyal Fenig; Dana Stein; Gwen Nichols; Thomas N. Denny; Joachim Yahalom; Robert Wieder


Book ID
115602853
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
404 KB
Volume
238
Category
Article
ISSN
0014-4827

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Overexpression of basic fibroblast growt
✍ Robert Wieder; Eyal Fenig; Huisheng Wang; Qin Wang; Shoshana Paglin; Thomas Menz πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 606 KB

Basic fibroblast growth factor (bFGF, FGF-2) is progressively lost from mammary epithelial cells as they become malignant. To investigate the effects of restoring the expression of bFGF in breast cancer cells, we constructed MCF-7 cells that permanently overexpress 18-kD cytoplasm-localizing bFGF (M