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Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells

✍ Scribed by Hongyan Gu; Shuyun Rao; Jie Zhao; Jia Wang; Rong Mu; Jingjing Rong; Lei Tao; Qi Qi; Qidong You; Qinglong Guo

Publisher: Springer-Verlag
Year: 2009
Tongue: English
Weight: 413 KB
Volume: 135
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-009-0624-2

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## Abstract Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We reported recently that roscovitine (ROSC), a potent cyclin‐dependent kinase 2 inhibitor, arrests human MCF‐7 breast cancer cells in the G~2~ phase of the cell