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Uptake mechanism of irinotecan (CPT-11) and its metabolite (SN-38) by hamster intestinal cells

✍ Scribed by Kobayashi, K.; Bouscarel, B.; Matsuzaki, Y.; Ceryak, S.; Fromm, H.


Book ID
122680332
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
344 KB
Volume
114
Category
Article
ISSN
0016-5085

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pH-dependent uptake of irinotecan and it
✍ Kunihiko Kobayashi; Bernard Bouscarel; Yasushi Matsuzaki; Susan Ceryak; Shoji Ku πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 153 KB

Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38