pH-dependent uptake of irinotecan and it
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Kunihiko Kobayashi; Bernard Bouscarel; Yasushi Matsuzaki; Susan Ceryak; Shoji Ku
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Article
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1999
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John Wiley and Sons
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French
β 153 KB
Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38