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Effect of bile acids on the uptake of irinotecan and its active metabolite, SN-38, by intestinal cells

โœ Scribed by Kunihiko Kobayashi; Susan Ceryak; Yasushi Matsuzaki; Shoji Kudoh; Bernard Bouscarel

Book ID
117480751
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
185 KB
Volume
1525
Category
Article
ISSN
0304-4165

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pH-dependent uptake of irinotecan and it
pH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells
โœ Kunihiko Kobayashi; Bernard Bouscarel; Yasushi Matsuzaki; Susan Ceryak; Shoji Ku ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 153 KB

Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38