Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38
Uptake of irinotecan metabolite SN-38 by the human intestinal cell line Caco-2
β Scribed by Tatsuya Itoh; Shirou Itagaki; Yoshinobu Sumi; Takeshi Hirano; Isao Takemoto; Ken Iseki
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 198 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0344-5704
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