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Glucuronidation of SN-38, the Active Metabolite of Irinotecan, by Human Hepatic Microsomes

✍ Scribed by Haaz, Marie-Christine ;Rivory, Laurent ;Jantet, Sophie ;Ratanasavanh, Damrong ;Robert, Jacques

Book ID
111262437
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
554 KB
Volume
80
Category
Article
ISSN
0901-9928

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## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated

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Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38