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Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide

โœ Scribed by Klein, C


Book ID
111727984
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
129 KB
Volume
72
Category
Article
ISSN
0009-9236

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pH-dependent uptake of irinotecan and it
โœ Kunihiko Kobayashi; Bernard Bouscarel; Yasushi Matsuzaki; Susan Ceryak; Shoji Ku ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 153 KB

Irinotecan (CPT-11) and its active metabolite, 7-ethyl-10hydroxycamptothecin (SN-38), are believed to be reabsorbed by intestinal cells and to enter the entero-hepatic circulation, but there is little information to date. Our objective was to investigate the intestinal transport of CPT-11 and SN-38