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Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

โœ Scribed by Laurent P. Rivory; Mark R. Bowles; Jacques Robert; Susan M. Pond


Book ID
115784683
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
938 KB
Volume
52
Category
Article
ISSN
0006-2952

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High-performance liquid chromatographic
โœ Nobumitsu Hanioka; Hideto Jinno; Tetsuji Nishimura; Masanori Ando; Shogo Ozawa; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 116 KB ๐Ÿ‘ 1 views

## Abstract A simple and sensitive assay for glucuronidation activity of 7โ€ethylโ€10โ€hydroxycamptothecin (SNโ€38), the active metabolite of irinotecan (CPTโ€11), in human liver microsomes by highโ€performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated