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Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)

✍ Scribed by Gagne, J.-F.


Book ID
111913986
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2002
Tongue
English
Weight
447 KB
Volume
62
Category
Article
ISSN
0026-895X

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High-performance liquid chromatographic
✍ Nobumitsu Hanioka; Hideto Jinno; Tetsuji Nishimura; Masanori Ando; Shogo Ozawa; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 116 KB πŸ‘ 1 views

## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated