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In Vitro Binding and Partitioning of Irinotecan (CPT-11) and its Metabolite, SN-38, in Human Blood

✍ Scribed by Olivier Combes; Jérôme Barré; Jean-Claude Duché; Laurent Vernillet; Yves Archimbaud; Michael P. Marietta; Jean-Paul Tillement; Saïk Urien

Book ID: 110234785
Publisher: Springer US
Year: 2000
Tongue: English
Weight: 51 KB
Volume: 18
Category: Article
ISSN: 0167-6997
DOI: 10.1023/a:1006379730137

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## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated