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In vitro conversion of irinotecan to SN-38 in human plasma

✍ Scribed by Masato Shingyoji; Yuichi Takiguchi; Reiko Watanabe-Uruma; Yoshiko Asaka-Amano; Hiroshi Matsubara; Katsushi Kurosu; Yasunori Kasahara; Nobuhiro Tanabe; Koichiro Tatsumi; Takayuki Kuriyama

Book ID: 108583420
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 153 KB
Volume: 95
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2004.tb03245.x

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## Abstract Overcoming drug resistance has become an important issue in cancer chemotherapy. Among all known mechanisms that confer resistance, active efflux of chemotherapeutic agents by proteins from the ATP‐binding cassette family has been extensively reported. The aim of the present study was t