Two-dimensional heteronuclear NOE spectroscopy; Application to 19F-labeled oligodeoxyribonucleotides
โ Scribed by William J Metzler; Philip Leighton; Ponzy Lu
- Book ID
- 107798231
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 332 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-2364
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The novel application of 2D heteronuclear NMR experiments to a single-stranded RNA fragment 5'-GCAU\*GGCU\*ACU\*U\*-3' labelled with 5-fluorouridine (U\*) at four sites is reported. Heteronuclear equivalents of COSY and NOESY experiments are described, both implemented in the phase-sensitive mode. T
## Abstract Several new protonโdetected heteronuclear twoโdimensional (2D) nmr techniques are presented that exhibit the features of __selection__ and __editing__ of multiplicity. The theoretical basis of the new features is briefly discussed and the application of the 2D techniques to a thioanalog
Li, 'H HOESY was used both for the detection of short lithiurnproton distances and for proton spectral assignments of l,&ddithio-l,%diphenylhex-l-ene, which exists as a monomer-dimer equilibrium mixture in tetrahydrofuran (THF-d,). Experiments using magnitude mode, pure absorption and pseudo-steady-