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Heteronuclear two-and three-dimensional nmr spectroscopy of 13C in natural abundance by multiplicity selection and editing: Application to peptides

✍ Scribed by H. Kessler; P. Schmieder

Publisher
Wiley (John Wiley & Sons)
Year
1991
Tongue
English
Weight
503 KB
Volume
31
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Several new proton‐detected heteronuclear two‐dimensional (2D) nmr techniques are presented that exhibit the features of selection and editing of multiplicity. The theoretical basis of the new features is briefly discussed and the application of the 2D techniques to a thioanalogon of Cyclosporin A [Thio‐(1)‐cyclosporin A] is shown. In addition, an extension of the experiments to three‐dimensional (3D) techniques is demonstrated and the application of two 3D techniques to Thio‐(1)‐cyclosporin A with ^13^C in natural abundance is presented. The new techniques can help simplify heteronuclear shift correlations and increase the resolution in the carbon dimension.

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