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Tritium labelling of psychopharmacologic agents

✍ Scribed by Ouri Buchman; Michael Shimoni

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 362 KB
Volume: 19
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580190117

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✦ Synopsis

Abstract

Attempts to reach phenothiazine derivatives labelled with tritium at high specific activity, are described. All the syntheses are based on catalysed dehalogenation procedures. The most encouraging results are those obtained by halogenation of the desired compound followed by catalytic dehalogenation with Pd/C. The specific activities are in the range of 10,000‐40,000 mCi/mmol.

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