## Abstract The synthesis of tritium labelled nitroaryldihydropyridines was achieved by dehalogenation of a brominated precursor using the palladium hydroxide on charcoal as catalyst. The investigations described show the example [^3^H]nimodipine which was prepared with a specific activity of 16,4
Tritium labelling of polyols
β Scribed by G. P. Akulov; E. V. Snetkova; Ju. L. Kaminski; B. K. Kudelin; V. L. Efimova
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 122 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Mannitol, galactitol and myoβinositol were labelled by a solid state isotope exchange with gaseous tritium. The labelled polyois were prepared with specific activities in the range 740β4440 TBq/mol (20β120 kCi/mol) after purification by HPLC.
π SIMILAR VOLUMES
## Abstract Attempts to reach phenothiazine derivatives labelled with tritium at high specific activity, are described. All the syntheses are based on catalysed dehalogenation procedures. The most encouraging results are those obtained by halogenation of the desired compound followed by catalytic d
## Abstract A convenient method is described to label a local anesthetic, benzocaine, with tritium. The bromoester of __para__ β aminobenzoic acid (PABA) was prepared from __para__βnitrotoluene and was reduced with tritium. The generation of isotopic hydrogen and labelling of benzocaine was achieve
Methods f o r t r i t i a t i o n o f s u l p i r i d e , s u l t o p r i d e and metoclopramide were H-metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination o f the developed and optimized. 3 H -s u l p i r i d e (7.1 Ci/mmol), 3H-sultopride (2.1 Ci/mmol) and r e l a t e d bromo d e r i
Methods are described for tcitiating compounds containing both chlorine or a double bond and bromine by highly-selective debromination to give the chlorine-containing or unsaturated 3H-compounds with specific activities of 10-28 Ci/maOl.