✦ LIBER ✦

Labelling of benzocaina with tritium

✍ Scribed by Sohail Malik

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 114 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580341013

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✦ Synopsis

Abstract

A convenient method is described to label a local anesthetic, benzocaine, with tritium. The bromoester of para — aminobenzoic acid (PABA) was prepared from para‐nitrotoluene and was reduced with tritium. The generation of isotopic hydrogen and labelling of benzocaine was achieved in one‐step. A mixture of sodium borohydride (NaB^3^H~4~) with cobalt (II) chloride was used to generate tritium gas. 5% Pd/C was used as a catalyst. This constitutes the first report of tritium labelled benzocaine.

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