## Abstract The synthesis of tritium labelled nitroaryldihydropyridines was achieved by dehalogenation of a brominated precursor using the palladium hydroxide on charcoal as catalyst. The investigations described show the example [^3^H]nimodipine which was prepared with a specific activity of 16,4
Tritium-labelling of lipids
β Scribed by V. P. Shevchenko; N. F. Myasoedov
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 562 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Tritiumβlabelled lipid preparations are obtained by heterogeneous isotopic exchange with gaseous tritium in solution. After appropriate purification, the localization of the label was determined in the main fragments of [^3^H]βcompounds. The obtained data on specific radioactivity and the pattern of label localization allow an insight into processes taking place on labelling under particular experimental conditions.
π SIMILAR VOLUMES
## Abstract Mannitol, galactitol and myoβinositol were labelled by a solid state isotope exchange with gaseous tritium. The labelled polyois were prepared with specific activities in the range 740β4440 TBq/mol (20β120 kCi/mol) after purification by HPLC.
## Abstract Attempts to reach phenothiazine derivatives labelled with tritium at high specific activity, are described. All the syntheses are based on catalysed dehalogenation procedures. The most encouraging results are those obtained by halogenation of the desired compound followed by catalytic d
## Abstract A convenient method is described to label a local anesthetic, benzocaine, with tritium. The bromoester of __para__ β aminobenzoic acid (PABA) was prepared from __para__βnitrotoluene and was reduced with tritium. The generation of isotopic hydrogen and labelling of benzocaine was achieve
Methods f o r t r i t i a t i o n o f s u l p i r i d e , s u l t o p r i d e and metoclopramide were H-metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination o f the developed and optimized. 3 H -s u l p i r i d e (7.1 Ci/mmol), 3H-sultopride (2.1 Ci/mmol) and r e l a t e d bromo d e r i