## Department of Chemistry Labelled Compounds and Metabolite Synthesis Group 31, avenue Paul Vaillant-Couturier 92220 BAGNEUX (FRANCE) SmOuRY The synthesis of betaxolol, a new 8-blocking agent. labelled with tritium in high specific activity ('19 Ci/mmol) is described. The tritium was incorporated
Tritium labelling of carcinogenic cyclopenta[a]phenanthrenes at very high specific activity
β Scribed by Maurice M. Coombs
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 192 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Platinum metal catalysed exchange in [^3^H]acetic acid is a satisfactory method for generally labelling cyclopenta[a]βphenanthrenes at very high specific activity.
π SIMILAR VOLUMES
Dz binding properties, i s described. The pyrrolidine moiety of the molecule i s labelled with tritium by hydrogenation, to a specific a c t i v i t y o f up to 58 Ci/mnol and subsequently reacted with an acid chloride. The specificity o f the label i s confirmed by 'H-"R.
## Abstract Tritiated hydrocarbons may be prepared by Kolbe electrolysis of carboxylic acids which have been labelled by catalytic exchange in tritiated water.
Hydrogen-tritium exchange labelling methods proved to be unsatisfactory for the preparation of tritiated DL-a-tocopherol at high specific activity. The preparation of a-tocopherol specijcally labelled in the 5-methyl hydrogen positions is described : the method permits specific activities in the cur