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Transport and Metabolism of the Tea Flavonoid (–)-Epicatechin by the Human Intestinal Cell Line Caco-2

✍ Scribed by Jaya Bharathi Vaidyanathan; Thomas Walle

Book ID
110309329
Publisher
Springer US
Year
2001
Tongue
English
Weight
218 KB
Volume
18
Category
Article
ISSN
0724-8741

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi