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Metabolism, Uptake, and Transepithelial Transport of the Stereoisomers of Val-Val-Val in the Human Intestinal Cell Line, Caco-2

✍ Scribed by Kiyoshi Tamura; Chao-Pin Lee; Philip L. Smith; Ronald T. Borchardt


Book ID
110348478
Publisher
Springer US
Year
1996
Tongue
English
Weight
978 KB
Volume
13
Category
Article
ISSN
0724-8741

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi