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Transepithelial transport of bepridil in the human intestinal cell line, Caco-2, using a “dynamic model”

✍ Scribed by F. Mathieu; M. -J. Galmier; A. Nicolay; J. -F. Pognat; C. Lartigue


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
634 KB
Volume
28
Category
Article
ISSN
0378-7966

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi