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Transport of quercetin di-sodium salt in the human intestinal epithelial Caco-2 cell monolayer 139

✍ Scribed by H. A. Milane; A. Al Ahmad; M. Naitchabane; T. F. Vandamme; L. Jung; G. Ubeaud

Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
863 KB
Volume
32
Category
Article
ISSN
0378-7966

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi