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Characterization of the transport of the organic cation [3H]MPP+in human intestinal epithelial (Caco-2) cells

✍ Scribed by F. Martel; C. Calhau; I. Azevedo


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
125 KB
Volume
361
Category
Article
ISSN
0028-1298

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi