𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications

✍ Scribed by V. Meunier; M. Bourrié; Y. Berger; G. Fabre

Book ID
104929539
Publisher
Springer
Year
1995
Tongue
English
Weight
1019 KB
Volume
11
Category
Article
ISSN
0742-2091

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi