𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Traceless synthesis of 3H-quinazolin-4-ones via a combination of solid-phase and solution methodologies

✍ Scribed by Donogh J.R. O'Mahony; Viktor Krchňák

Book ID
104232309
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
119 KB
Volume
43
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A solid-phase traceless synthesis of quinazolin-4-ones is described. An aldehyde functionalized resin was reductively aminated with primary amines, and the resin-bound secondary amine acylated with o-nitro-benzoic acids. The nitro group was reduced with tin(II) chloride, and the aniline acylated with acid anhydrides. Acidolytic cleavage afforded a diamide, which was cyclized in solution phase to the 3H-quinazolin-4-one removing the trace of the linker.

📜 SIMILAR VOLUMES

Solid-phase synthesis of quinazolin-4(3H
Solid-phase synthesis of quinazolin-4(3H)-ones with three-point diversity
✍ A.P. Kesarwani; G.K. Srivastava; S.K. Rastogi; B. Kundu 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 68 KB

A versatile method for the solid-phase synthesis of differentially substituted quinazolin-4(3H)-ones has been developed using immobilized arylguanidines. The latter were obtained by treating the amino group of polymer-linked anthranilamide with isothiocyanates followed by coupling with secondary ami

ChemInform Abstract: Synthesis of Substi
ChemInform Abstract: Synthesis of Substituted Quinazolin-4(3H)-ones and Quinazolines via Directed Lithiation
✍ Gamal A. El-Hiti 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v