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Solid-phase synthesis of quinazolin-4(3H)-ones with three-point diversity

✍ Scribed by A.P. Kesarwani; G.K. Srivastava; S.K. Rastogi; B. Kundu

Book ID
104251545
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
68 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A versatile method for the solid-phase synthesis of differentially substituted quinazolin-4(3H)-ones has been developed using immobilized arylguanidines. The latter were obtained by treating the amino group of polymer-linked anthranilamide with isothiocyanates followed by coupling with secondary amines in the presence of DIC. Finally a cyclative cleavage strategy was applied to give the desired compounds in high yields and purities.

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