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TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility

โœ Scribed by Thuy N. Do; Esma Ucisik-Akkaya; Charronne F. Davis; Brittany A. Morrison; M. Tevfik Dorak

Book ID
113513585
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
119 KB
Volume
195
Category
Article
ISSN
0165-4608

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โœ Xiujuan Xiong; Min Wang; Lin Wang; Jiazhuo Liu; Xin Zhao; Zheng Tian; Jianxiang ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 160 KB

A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a